Abstract
(1) The endogenous, NADPH-supported production of H 2O 2 and of O 2 .−-radicals in rat liver microsomes was very strongly enhanced in the presence of anthraquinone-2-sulfonic acid (AQSA). (2) This induction of H 2O 2 and of O 2 .−-radicals was catalyzed by the microsomal NADPH:cytochrome P450 oxidoreductase (EC 1.6.2.4). (3) AQSA was reduced to AQSA radicals by reductase AQSA radicals reduce molecular oxygen to O 2 .−-radicals, which are readily dismutated to H 2O 2 by the microsomal Superoxide dismutase. (4) O 2 .−-radicals are the sole precursors of all AQSA-induced production of H 2O 2 in liver microsomes.
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