Abstract
Studies are presented in two male patients with primary hyperparathyroidism who had developed salt-wasting nephropathy in the course of their disease. Both of them had nephrocalcinosis and markedly impaired renal function and exhibited an abnormal decrease in the fraction of filtered sodium reabsorbed by the renal tubules. Both patients showed impaired intestinal absorption and negative balances of calcium and phosphorous and had osteitis fibrosa cystica. Thus salt-wasting nephropathy is an additional and previously undescribed complication of primary hyperparathyroidism.
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