Abstract
RATIONALE: The signals leading to mast cell degranulation, namely Fcε RI crosslinking, have been subject to intense investigations. However, the last events facilitating the fusion of granule and plasma membrane are still elusive. SNARE (Soluble NSF Attachment Protein Receptors) proteins are known to mediate the synaptic transmission. We analyzed whether human mast cell express SNAREs and which of them might be crucial for mast cell degranulation.
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