Abstract
Preliminary observations on the infectivity of trachoma-inclusion conjunctivitis organisms in primary (normal) human amniotic epithelial cells derived from 9 different amnions showed a considerable variation in the sensitivity of these cells toward the pathogens. There was also a remarkable diversity of inclusion-and chlamydial particle morphology in primary epithelial cells by light microscopy and immunofluorescence as compared to the inclusion morphology in L cells (continuous cell line of mouse fibroblasts). Present studies suggest that primary human amniotic epithelial cells could provide a convenient system to further explore the interaction of the strictly human chlamydial pathogen with normal human cells.
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