Abstract
A retrospective analysis was performed upon 175 patients with Non-Hodgkin's Lymphoma involving the gastrointestinal tract and entered into BNLI trials and studies between 1974-1988. Malignant histiocytosis of the intestine (MHI), which was present in 16 patients, was associated with a survival of less than 25% at 18 months, and probably accounted for the poor survival of patients with jejunal involvement. Histopathological evidence of tumour origin from mucosa-associated lymphoid tissue (MALT) was found in 50% of patients with gastric involvement and in 27% of those with intestinal involvement. The overall survival of the series as a whole was 44% at 10 years. Multivariate analysis identified evidence of tumour origin from MALT as the only factor to attain prognostic significance in patients with gastric involvement, and clinical stage and the presence of MHI as the only factors to attain prognostic significance in patients with intestinal involvement. It is suggested that there is a need for a large multicentre prospective study of GIT lymphoma.
Highlights
Operation details were unavailable for 42 patients
Most patients were classified as belonging to the diffuse large cell subtype (41%) or to the mucosa-associated lymphoid tissue (MALT) subtype (35%); a further 9% were classified as Malignant histiocytosis of the intestine (MHI)
Two per cent of the series were classified as multiple lymphomatous polyposis (MLP)
Summary
The series consisted of 175 patients with primary gastrointestinal (GI) NHL, namely those whose main presenting feature was related to the GI tract or in which the predominant lesion was clearly in the GI tract, who were entered into BNLI studies between 1974 and 1988. Diagnostic material was obtained either at laparotomy or by endoscopic biopsy. Partial, or no surgical resection, followed by either chemotherapy (CT), radiotherapy (RT), both of these modalities in combination (RT + CT), or no further treatment, according to the protocol of the time. Surgery was not always performed at the referral centre and Correspondence: G. Vaughan Hudson, BNLI, Department of Oncology, The Middlesex Hospital, Mortimer Street, London, WIN 8AA, UK. Received 30 July 1992; and in revised form 10 November 1992
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