Abstract
Primary angiosarcoma of the breast is an extremely rare tumour with a difficult diagnosis and poor prognosis. We report a case of primary breast angiosarcoma diagnosed in the pathology department of the University Hospital of Oujda. An analysis of the epidemiological, diagnostic and therapeutic aspects of this type of tumour is made in this manuscript. Mastectomy is the standard treatment; the place of radiotherapy and chemotherapy is not well established. We report a case of a 18- year-old woman having an infectious symptomatology of the right breast for which she received an anti-infectious therapy inducing regression of inflammatory symptoms presented with a quick growing mass. Initial core needle biopsy showed a malignant vascular proliferation. The patient underwent a mastectomy. The tumor histology showed papillary formations and vascular structures lined by atypical cells with hyperchromatic nucleus and eosinophilic cytoplasm. The tumor cells expressed CD34 and CD31 but were negative for cytokeratin. The diagnosis of angiosarcoma grade I was made. The patient is now receiving chemotherapy. She is still alive.
Highlights
Angiosarcomas of the breast are very rare malignant tumours accounting for less than 0.05% [1] of all breast conjunctive vascular tumours. They are characterized by a high malignity and a fast growth rate [2] and evolve to rapid local recurrence and the appearance of visceral metastases
The treatment is based on simple mastectomy
An 18 year-old woman referred having an infectious symptomatology of the right breast 5 months ago for which she received an antiinfectious therapy inducing regression of inflammatory symptoms presented with a quick growing mass involving the two inferior quadrants of the right breast, but did not consult any doctor until it reached 10cm in its size. She had no history of breast trauma and no breast cancer in her family
Summary
Angiosarcomas of the breast are very rare malignant tumours accounting for less than 0.05% [1] of all breast conjunctive vascular tumours. An 18 year-old woman referred having an infectious symptomatology of the right breast 5 months ago for which she received an antiinfectious therapy inducing regression of inflammatory symptoms presented with a quick growing mass involving the two inferior quadrants of the right breast, but did not consult any doctor until it reached 10cm in its size. She had no history of breast trauma and no breast cancer in her family.
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