PREVENTION OF PREMATURE LABOR IN PREGNANT WOMEN WITH PREVIOUS PREVENTION

Abstract

Introduction.The problem of preterm labor is always relevant component of all complications of pregnancy. One of the most promising methods for predicting preterm labor is, at present, the detection of fetal fibronectin (fFN) and the determination of the content of interleukins in the blood or cervical secretions, in particular, the importance of interleukin 8 (IL-8).Aim. Determine the efficiency of prediction of preterm labor by simultaneously identifying fFN and IL-8 as markers of probable preterm labor.Materials and methods. Clinical and laboratory examination of 60 pregnant women was carried out: 40 - the main group with false contractions up to 37 weeks; 20 - control group, pregnant without this pathology. Definition of fFN andIL-8 was performed simultaneously in blood serum and cervical mucus with the evaluation of the results on the Rider Myltiskan EX immuno-enzyme analyzer using a set of reagents and test systems.Research results. An analysis of the effectiveness of diagnosis of preterm labor in pregnant women with false contractions up to 37 weeks using transvaginal cervicomercia revealed a shortening of the cervix in terms of 22-27 weeks in 5% and in 31-33 weeks in 10% and changes from the FF values in terms of 22- 27 weeks and 28-33 weeks - where its level was elevated both in serum and in cervical mucus and was 331.5 ± 40.4 and 1510 ± 17.9 respectively; 349.3 ± 45.2 and 128.6 ± 22.7 ng / ml. The probable correlation between increased fetal fibronectin and structural changes in the cervix was established (the correlation coefficient of the reciprocal connection was R = 0.50). Taking into account the data of urogenital stroke and the content of IL-8 in cervical mucus, it was found that an increase in the number of leukocytes, indicating inflammation, and an increase in IL-8 in 47.8% during the period of pregnancy 22-27 weeks + 6 days and in the 31- 33 weeks + 6 days in 55.6%, where the mean IL-8 was 132.5 ng / ml and 33.3% of the background cervical cancer.Conclusions. In the presence of false breaks and premature births, regardless of the period of pregnancy, there is a significant increase in IL-8. The probable correlation between increased fetal fibronectin in blood serum and in cervical mucus and structural changes in the cervix (correlation coefficient of mutual communication was R = 0.50) was established.