Prevention of microcirculatory disorders in rats on suprathreshold physical exertion using the products of velvet antler industry

Abstract

Aim. To assess the microcirculatory bloodstream after suprathreshold physical load in rats with preceding intake of products of velvet antler industry, as well as to determine which microcirculatory reactions cause the adaptive effect. Methods. The study included 30 male Wistar rats. Two groups of experimental animals received the concentrate containing blood and histolysate of Siberian stag reproductive organs, 4.5 ml per day. The rats of the first experimental group were subjected to an 8-hour physical load on day 31, and rats of the second group were not subjected to the load. Indices of microcirculation obtained by laser Doppler flowmetry in experimental animals were compared to those of intact rats. Results. In animals of the first experimental group, the amplitude of respiratory waves increased in comparison with intact animals, while the remaining indices of the microcirculation system did not differ from those of the intact group. In the rats of the second experimental group, there was an increase in the flax, which indicates an increase in the modulation of the blood flow; in rats an increase in the amplitude of endothelial and vasomotor waves was revealed in comparison with intact animals against the background of constant amplitudes of respiratory and pulse waves. Conclusion. Preceding 30-day intake of a concentrate containing blood and histolysate of Siberian stag reproductive organs, in general, was found to prevent the development of disturbances of the microcirculatory bloodstream in rats after the suprathreshold physical load due to active mechanisms of blood flow regulation - increase of the amplitudes of endothelial and vasomotor waves.