Abstract
The article presents the results of preventive efficacy of hepatoprotectors Hep-A-Stress and Hepasan-VS in laying hens with hepatosis. The research was conducted in modern poultry farm. Three groups of laying hens (control and two experimental) Lohmann Brown breed (n = 1500) aged 224 days were formed. The poultry was kept on the main ration according to the technological map for the use of this breed. Laying hens from the first experimental group were additionally given hepatoprotector Hep-A-Stress and the second – Hepasan-VS. Blood sampling for the study was performed three times: before the start of drug administration, after 10 and 30 days from the beginning of hepatorotectors administration. The prophylactic effect of these drugs was determined by studying the preservation and productivity of poultry, interpretation of biochemical analysis of blood serum. The use of hepatoprotectors has allowed to increase the preservation and egg production of laying hens. The results of our studies showed insignificant changes of biochemical parameters in blood after 10 days administration of drugs, which indicates a slow effect of hepatoprotectors on the regenerative processes in the body of poultry. The prophylactic effect was established after 30 days use of hepatoprotectors. Our results showed that the use of these drugs had a positive effect on the protein-synthesizing function of the liver, as indicated by a decrease in serum total protein and an increase a albumin contents. There was also a positive effect on the intensity of protein metabolism, indicated by decreased uric acid and an increased urea in the blood serum of experimental groups. The use of hepatoprotectors helped to reduce the activity of hepatospecific enzymes AST and ALT, which indicates the stabilization of cellular structures of hepatocytes. These drugs have increased the function of bile secretion, which is key of lipid metabolism, as evidenced by an increase in serum cholesterol. Thus, the use of these hepatoprotectors has a positive effect on metabolic processes in the body of laying hens, in particular, normalizes liver function and prevents the development of hepatosis.
Highlights
The dynamic growth of the number of poultry of all species is a feature of the current state of development of the poultry industry of Ukraine during the last decade (Melnyk & Ponomar, 2014; Melnyk, 2015)
During the examination of poultry, metabolic disorders were diagnosed, which accounted for 90 % of pathologies of non-contagious etiology, and in 80 % of cases liver diseases were diagnosed
The analysis of the obtained data made it possible to determine the nature of metabolic pathology, to identify the subclinical course of hepatosis in laying hens and to apply preventive measures, the ultimate goal of which is preservation of poultry and increase of its productivity (Dunets & Slivinska, 2018)
Summary
The dynamic growth of the number of poultry of all species is a feature of the current state of development of the poultry industry of Ukraine during the last decade (Melnyk & Ponomar, 2014; Melnyk, 2015). In the structure of non-contagious diseases of poultry, according to a number of authors (Bessarov et al, 2009; Kal'berg & Sadovnykov, 2010; Sokolov & Ivannikov, 2013; Melnyk, 2014), liver pathology (hepatosis or hepatodystrophy, hepatitis and liver cirrhosis) are diagnosed in 5.0–50.8 %. Timely diagnosis of the functional state of the liver of laying hens is actual, as pathological processes of this organ lead to irreversible processes, the development of disease and death (Dunets & Slivinslka, 2018; Ostapyuk & Gutyj, 2019). Research on the impact of the development of liver pathologies on the productivity of poultry, which directly depend from the state of metabolic processes in the body, is gaining actual. The study of comprehensive and deep mechanisms of biochemical processes regulation in the body of poultry using drugs of different directions, primarily having hepatoprotective and anti-stress properties (Zhang et al, 2008; Ermashkevich & Kletikova, 2016)
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