Abstract
This study was done to determine whether peritonitis caused by osmotic dysequilibrium could be prevented by pretreatment. Young adult rats were used after induction of peritonitis by intraperitoneal injections of large volumes of pure water to create severe osmotic dysequilibrium. During the 1 or 2 weeks before induction of peritonitis, the rats were pretreated by intraperitoneal injections of small volumes of pure water or large volumes of moderately hypotonic electrolytes to produce a slight degree of osmotic dysequilibrium. Peritonitis was evaluated by macroscopic and microscopic study of peritoneal tissues. The severity of peritonitis was greatly reduced by the pretreatments. This study adds the peritoneum to the list of tissues in which adaptation to an injury can be accomplished by pretreatment with the same injurious agent, albeit in a less noxious form.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
