PREVALENCE OF THYROID AUTO-ANTIBODIES IN DERANGED THYROID PROFILE, 6-YEAR STUDY IN AN INDIAN REFERENCE LABORATORY

Abstract

Introduction:Autoimmune thyroid disorder is the most common cause of hypothyroidism seen in adults. Anti-TPO and anti-TG play a vital role in lab diagnosis of autoimmune thyroid disorder. In our present study we have tried to establish a correlation between anti-TPO & anti-TG levels with various thyroid parameters Aims and Objectives: Ÿ To study prevalence of Anti-thyroid antibodies, which are specic for autoimmune thyroiditis, in deranged thyroid prole across Indian population Ÿ To study prevalence of Anti-TPO antibodies across adult population Ÿ To establish co-relation between TSH level and Anti-TPO antibody value Method: We did a retrospective analysis of Thyroid Prole data obtained at a referral laboratory based in Mumbai over a span of 6 years (2016-2021). Population studied belonged to the city of Mumbai metropolitan region. The separation and quantication of T3, T4, TSH, FT3, FT4, ATG & TPO in serum was done on the Cobas e-411/e-601/e801analysrs. Total of 3342 cases were studied in the age group of 18 years - 60years. We compared & correlated results according to gender and age. Results: The incidence and prevalence of ATG and TPO antibodies were more in females as compared to males. For TPO antibodies P value being 0.0013 and for ATG antibodies, P value being 0.0002 Anti-TPO level had positive correlation with ATG level. (Coefcient of correlation 0.3285) (P value-0.0001). Also Anti-TPO antibodies had positive correlation with TSH levels (Coefcient of correlation 0.2207) (P value 0.0001) Conclusion: Anti-TPO antibodies are commonly associated with thyroid dysfunction followed by Anti-TG antibodies. They are most commonly seen in 36-45 years of age group.