Abstract
BackgroundAtherosclerotic disorders, hypertension and lipid profile alterations are of a lower prevalence in patients with minor beta thalassemia. On the other hand, nowadays, metabolic syndrome is considered as one of the major risk factors of developing cardiovascular diseases. Therefore, the present study was performed to determine the prevalence of metabolic syndrome in patients with minor beta thalassemia.MethodsIn this case-control study, body length, weight and waist circumference, blood pressure, fasting blood sugar [FBS], triglyceride, cholesterol, HDL, and LDL levels were determined in 150 patients with minor beta thalassemia and 300 healthy individuals as control group [matched based on age and sex]. The prevalence of metabolic syndrome was calculated based on ATPIII criteria. Data were analyzed through SPSS16 software package.ResultsThe prevalence of metabolic syndrome was 12.7% in the thalassemia group and 36.7% in the control group [p < 0.0001]. In the patient group, 3 ones [8.3%] of those with metabolic syndrome were male and 16 ones [14%] were female [p = 0.5]. Mean age of patients with metabolic syndrome was 39.4 ± 8.5 years and mean age of those without metabolic syndrome was 36.4 ± 7.8 years [p = 0.1]. Mean BMI of those with metabolic syndrome was 31.3 ± 4.1 kg/m2 and that of those without metabolic syndrome was 24.2 ± 4.4 kg/m2 [p < 0.0001].ConclusionsThe obtained results show lower prevalence of metabolic syndrome in patients with minor thalassemia. Moreover, the prevalence of metabolic syndrome in patients with minor thalassemia showed no relationship with sex and age and these patients had just higher BMI.
Highlights
Since 1960s, a relationship has been found between cardiovascular diseases and high level of serum triglyceride, severe obesity, insulin resistance, glucose intolerance and hypertension [1,2,3,4]
Since insulin resistance has been considered as an underlying cause of risk factors and development of diabetes and cardiovascular diseases [5,6,7,8,9,10], insulin resistance syndrome was used as another term for metabolic syndrome [11]
There are several criteria for the diagnosis of metabolic syndrome, the most applicable one is clinical diagnosis based on specified criteria of ATPIII [Adult Treatment Panel III] and IDF [International Diabetes Federation] [5,6]
Summary
Since 1960s, a relationship has been found between cardiovascular diseases and high level of serum triglyceride, severe obesity, insulin resistance, glucose intolerance and hypertension [1,2,3,4]. In 1988, for the first time, Reavan suggested the term of metabolic syndrome for combination of these cardiovascular factors [5]. Since insulin resistance has been considered as an underlying cause of risk factors and development of diabetes and cardiovascular diseases [5,6,7,8,9,10], insulin resistance syndrome was used as another term for metabolic syndrome [11]. The prevalence of metabolic syndrome has been reported 33.7% in a study on blood sugar and lipid levels of Tehran citizens [11]. Nowadays, metabolic syndrome is considered as one of the major risk factors of developing cardiovascular diseases. The present study was performed to determine the prevalence of metabolic syndrome in patients with minor beta thalassemia
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