Prevalence of Ketosis-Prone Diabetes Mellitus in Specialist Hospital Sokoto, Nigeria

Abstract

Ketosis-prone diabetes mellitus is a diabetes subtype that occurs in adults with hyperglycemia and ketosis without evidence of autoimmunity. Ketosis-prone diabetes is one of the diabetes subtypes that are on the rise in our black community. This study was designed to estimate the prevalence of ketosis-prone diabetes mellitus at a specialist hospital, in Sokoto, Nigeria. Seventy patients were recruited, and demographic data of the patients were obtained using a prepared questionnaire. Biochemical parameters such Fasting plasma glucose, Plasma ketones, Glycated Hemoglobin, insulin, and Glutamic Acid Decarboxylase determined using a standard method. Insulin resistance and beta-cell function were determined using the homeostasis model and Aβ classification was adopted in the selection of KPDM among participants. A prevalence of 17.14% was recorded with a 1:1 ratio between males and females. prevalence of 50% (6:12), 25% (3:12), 8.3% (1:12), 8.3% (1:12), and 8.3% (1:12) were also recorded among Hausa, Yoruba, Fulani, Igbo and others respectively. A significant difference was observed in FPG, HOMA-IR and HOMA-B between male and female subjects with the female having a greater value at p<0.05. Also, a significant difference was observed among Hausa, Fulani, Yoruba, Igbo and others in PK, FPG, HOMA-IR and HOMA-B. Knowing the prevalence of ketosis-prone diabetes mellitus was important for proper management to reduce costs and avoid mortality.