Abstract

Introduction and Aim: One of the more common degenerative illnesses in the adult population is osteoarthritis (OA). Many etiological agents are responsible for this common disorder like aging, calcium deficiency, inflammatory syndromes, etc.,With reference to this, preventive measures can be adopted by proper diagnosis and treatment at the right stage. The goal of this research was to evaluate the causes of osteoarthritis of the knee in adults and to identify the inflammatory biomarkers. Materials and Methods: A population?based, case study among 600 adultsattending local hospitals inChennai and Kanchipuram district, Tamilnadu, India, was cross-examined from January 2017 to December 2018. All the data related to the study were collected by the postgraduate students, skilled health workers according to thedirection of thecorresponding author. Printedquestionairesand informed approval were obtained from all study participants. Diagnosing criteria for OA wereadopted from the Rheumatology College of America, and it was confirmed and verified in the region. Results: Around 600 adult patients were questioned, with 27.1 % having knee OA.The following measures like age, tobacco habit, illiteracy, lower socioeconomic class, positive family history of OA, diabetes, and hypertension were found to be highly linked with OA knee significantly in age greater than 50 in females (P < 0.05). Conclusion: The risk of OA was high in this area and serum biomarkers were evaluated. In the present study, the IL-2,IL-5,IL-6, and IL-10 were considered as biomarkers for osteoarthritis in acute and chronic stages. As a result, an effective preventative approach is required to reduce this burden.

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