Abstract
Objectives: This study aimed to investigate the relationship between nutritional status and Parkinson's disease (PD) features.Methods: The cohort was composed of 556 Parkinson's patients who were admitted to the hospital. Patients were categorized as normal nutrition or at risk of malnutrition/already malnourished. Questionnaires, physical examinations, and biochemical tests were conducted. The relationship between nutrition status and PD was analyzed using t-tests, χ2-tests, and logistic regression models.Results: The prevalence of malnutrition [defined as a Mini Nutritional Assessment (MNA) score <17] was 39.2%, and 30.3% of patients were at risk of malnutrition (17 ≤ MNA score ≤ 23.5). There was no difference in gender and age between the different nutrition groups (P < 0.05). Patients at risk of malnutrition and those who were malnourished had a longer course of disease, more severe motor symptoms, a higher stage of PD according to the Hoehn and Yahr (H-Y) classification, a lower body mass index (BMI) index, a lower cognitive score, higher levels of depression and anxiety, and more serious non-motor symptoms (P < 0.05) than patients with normal nutrition. There were differences in adenosine deaminase, albumin, phosphorus, chlorine, total protein, and uric acid between the two groups (P < 0.05). High Unified PD Rating Scale (UPDRS-III) scores, high H-Y stages, and dyskinesia were risk factors for malnutrition in PD patients, while high levels of total protein, uric acid, and chlorine were protective factors that led to good nutrition (P < 0.05).Conclusions: Our results showed that dyskinesia, disease severity, total protein levels, uric acid levels, and chlorine levels were associated with nutritional status among Chinese PD patients. The findings of this study indicate the significance of the early detection and prevention of malnutrition to improve the quality of life of PD patients.
Highlights
Parkinson’s disease (PD) is a chronic degenerative neurodegenerative disease
According to the Mini Nutritional Assessment (MNA) score, 171 patients had normal nutrition status, 167 patients were at risk of malnutrition and 218 patients were malnourished, which accounted for 30.8, 30.0, and 39.2% of the sample, respectively
Cereda believed that the MNA nutrition screening scale was suitable for elderly patients in UPDRS-III Hoehn and Yahr (H-Y) stage Dyskinesia total protein (TP) uric acid (UA) CL
Summary
Parkinson’s disease (PD) is a chronic degenerative neurodegenerative disease. The incidence of PD is ∼2% among individuals over 65 years old in China, accounting for more than 40% of the total number of PD patients in the world. Some studies have shown that some lifestyle interventions could improve the quality of life of PD patients, such as behavior therapy, sleep improvement, mood improvement, and physical exercise [2,3,4,5]. Few studies have examined the effect of nutritional status on the quality of life of patients with PD [6,7,8]. A study showed a negative association between the severity of motor impairment and total fat mass in patients with PD [7]. Another study showed that malnutrition in PD patients can cause olfactory and gustatory dysfunction [9].
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