Open Forum Infectious Diseases | VOL. 9
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Prevalence and characteristics of carriage of Neisseria meningitidis among young Israeli adults

Publication Date Sep 19, 2022

Abstract

Abstract Background no updated data currently exist regarding Neisseria meningitidis carriage and genomic epidemiology among young Israeli adults. Methods oropharyngeal swabs were collected from 1,801 military recruits at the day of recruitment during 2019. Neisseria meningitidis was detected and identified by culture and qPCR. Confirmed isolates were serotyped by qPCR and encapsulated strains underwent whole genome sequencing. Risk factors for carriage were determined by analyzing focused questionnaires using uni- and multivariate models. Genomic typing was performed by means of core genome multilocus sequence typing. Results carriage rates overall and of encapsulated strains were 20.1% and 6.7%, respectively. Genogroup B (49.2%) and Y (26.7%) were the most common encapsulated strains. Genogroups C, W and X were scarce and genogroup A was absent. The most notable clonal complexes were CC23 (n=30), CC32 (n=16) and CC44/41 (n=9). Carriage was significantly associated with smoking (OR=1.82, CI[1.43-2.33) and boarding school attendance prior to recruitment (OR=1.49, CI[1.14-1.96]). Conclusions the prevalence of meningococcal carriage among young Israeli adults is high, compared to similar studies in other developed countries. This might be due to sociocultural characteristics ...

Concepts

Young Israeli Adults Core Genome Multilocus Sequence Typing Encapsulated Strains Neisseria Meningitidis Carriage Neisseria Meningitidis Risk Factors For Carriage Disease In Israel Prevalence Of Carriage Genomic Epidemiology Genomic Typing

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No potential conflict of interest was reported by the authors. The conception and design of the study, acquisition of data, analysis and interpretatio...

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