Abstract
The objective of this study was to contrast the prevalence and species of colonization of Non-Candida albicans (NCAC) in the oral cavity of denture wearers and non-denture wearers; also asses associated risk factors of their colonization. A total of 208 subjects were studied: 104 denture wearers and 104 non-denture wearers, matched by age, sex, comprised the experimental control groups, respectively. Each subject was instructed to perform oral rinsing using a phosphate-buffered saline solution, which was expectorated processed for the recovery of Candida species on on Sabouraud dextrose agar. Isolates were identified by culturing on chromogenic Candida agar noting species-specific colony characteristics. There was a significant oral carriage rate of NCAC among denture wearers (5.83% versus 11.1% in controls) with associated risk factor (5.4) (PV<0.001). The most common isolated NCAC were C. Krusi C.tropicalis with significant OR (5.5 4.7 respectively). When co-infections were considered, there was highly significant association of C. albicans + C. krusi oral colonization in cases (OR=4.56, PV<0.001). There was a significant oral carriage rate of NCAC among male denture wearers (36.9%, OR=6.6, PV˂0.001). In addition, there was a significant rate of NCAC colonization with complete denture (rate= 50%, OR=2.4, PV= 0.02). While no significant increase associated with colonization of NCAC with partial, acrylic /or chrome cobalt denture. Based on the results of this study ability of NCAC were greater in denture wearers than non-denture wearers, also greater risk of NCAC were found with males, older ages, complete denture.
Highlights
The preponderance oral yeast infections are caused by members of the genus Candida
The rate was 50%, between oral carriage rate of Non-Candida albicans (NCAC) among female with a highly significant association between complete denture wearers comparing with non-denture wearer denture and contract of oral NCAC colonization females
Current study’s result, was similar to that reported by Chopde et al.,[28] in which extremes of age is more susceptible to oral NCAC colonization
Summary
The preponderance oral yeast infections are caused by members of the genus Candida. Candidiasis is an opportunistic infection due to pathological changes in the surface of oral mucosal cavity[1,2]. In the last twenty years, some Candida species, including C. glabrate, C. tropicalis, C. krusei, C. parapsilosis, have been isolated with increasing frequency from cases of Candidiasis[4,5,6]. Isolation identification the Candida spp. is useful in choosing correct treatment, as some species may be resistant to certain groups of antifungal drugs[7,8,9]. There are reports of numerous cases describing infection colonization of immune-compromised patients on longterm treatments of oral antifungal agents, drug resistant. Each subject was asked to rinse the mouth for 60 seconds with 10 ml of sterile posaconazole voriconazole; echinocandins, caspofunphosphate-buffered saline Hundred μl of the concentrated oral rinse was Studies to identify Candida species in patients with denture stomatitis have produced contradictory results[8].
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