Abstract
Pretreatment of Vicia faba root-tip meristems with a non-toxic dose of either hydrazine or N, N′-diformyl hydrazine prior to administration of MH (separated by 2 h) resulted in a significant reduction of the yield of MH-induced chromatid aberrations compared to control treatments (MH only). This ‘clastogenic adaptation’ was not observed when the alkylating agent TEM was used instead of MH. It is concluded that pretreatment with the hydrazines induces an error-free repair system which reduces MH-induced damage and that both hydrazines and MH are able to induce oxidative DNA lesions via radical formation.
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