Abstract
Pretibial myxedema, first described by Watson-Williams, in 1895, has been almost invariably associated with exophthalmos, and as a result, the same etiology has been proposed. Over 100 cases 1 have been reported. The disorder probably occurs more frequently than this number would indicate, because of the failure to make a specific search of the pretibial region on the routine physical examination. Grossly, pretibial myxedema characteristically appears as firm brown or orange-colored plaques bilaterally but not always symmetrically, on the lower anterior portion of the legs or dorsum of the feet. Initially only the skin over these areas is thickened, but later varying-sized plaques appear and develop a pigskin or orange-peel appearance. The advanced lesion may resemble brawny lymphedema. Microscopically these lesions have the appearance of classical myxedema. In the cutis one finds edema along with fraying and homogenization of the connective tissue. Large amounts of mucinousstaining material are deposited between
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.