Abstract
The presynaptic inhibition is the object of intensive research mainly in acute animal experiments. But studies on intact human beings have the advantage of any neurophysiological mechanism. The presynaptic inhibition in the arc of monosynaptic reflex from spindles is accessible for such a study. Monosynaptic reflex can be modulated only by two ways: by change of motoneuron pool excitability and by presynaptic inhibition and disinhib- ition. The descending tonic presynaptic inhibition of soleus H-reflex in healthy man was shown by Delwaide (1973). Presynaptic inhibition in monosynaptic arc was revealed during rhythmic stimulation of la afferents (low-frequency depression) and during muscle vibration (see Rudomin, 1980).
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