Abstract
We have developed a method for simultaneously measuring coronary artery pressure and diameter in intact, awake animals. Cattle were chronically instrumented with ultrasonic dimension gauges on the left common coronary artery. A high fidelity catheter-tip manometer was placed in the same vessel. Along with the coronary pressure-diameter measurements, simultaneous measurements of ECG, aortic pressure, left ventricular pressure, intrathoracic pressure, and the right atrial pressure were made in 5 calves and 1 dwarf cow. After the arteries had some time to recover from the trauma of the surgical intervention and instrumentation, we measured the pressure-diameter relationships at various post-operative time intervals. Control measurements were followed by measurements made after pharmacologic interventions in two of the animals. The various pressure-diameter curves are illustrated in this paper. In addition an empirical parameter of vessel wall stiffness, the pressure elastic modulus, ( E p ), was calculated. The average value of E p for the left coronary artery 24 h after surgery for the control state was 1.56 (±0.19 SEM) × 10 6 dyn/cm 2.
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