Preservation of the myocardial collagen framework by human growth hormone in experimental infarctions and reduction in the incidence of ventricular aneurysms

Abstract

We administered human growth hormone to a group of rats with experimental myocardial infarctions, in order to observe its action on the connective tissue repair process and the consequent effect on postinfarction ventricular aneurysms. Myocardial connective tissue displays a complex layout around each myocyte and among neighboring ones. It has been shown to be highly vulnerable to acute coronary ischemia which affects its diverse components in accordance with a precise timetable. The ultimate consequence of ischemia on connective tissue is the disappearance of intermyocytic links and the collagen weave that surrounds each cell. Damage to this collagen framework of the heart is responsible for the final disarray of myocytes, with a parallel effect to the myocytolytic actions of ischemia within the very structure of each cell. Hence, the appearance of postinfarction ventricular aneurysms seems to be related to failure in normal repair processes resulting from maturation of new collagen tissue into the area of myocardial necrosis. It has been shown that, besides the well-known actions on chondrocytes, hypothalamic-hypophyseal human growth hormone and somatomedins activate the fibroblasts. Adminstration of human growth hormone resulted in a significant decrease in the incidence of ventricular aneurysms. Scanning electron microscopy showed a good preservation of connective tissue components of myocardium. A different histological pattern of necrosis resulted in the treated group.