Abstract

To the Editor: Central centrifugal cicatricial alopecia (CCCA) is a primary cicatricial alopecia (PCA) that occurs most commonly in black women.1 Little is known about the pathogenesis of CCCA, yet it remains the most common cause of scarring hair loss in this population.2 Prominent destruction of sebaceous glands is a characteristic feature of PCAs; in lichen planopilaris (LPP), the prototypical PCA, loss of sebaceous glands has been attributed to decreased peroxisome proliferator-activated receptor gamma (PPARγ) expression.

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