Abstract
Biologic agents (BA) have profoundly changed the outcome of juvenile idiopathic arthritis (JIA), making inactive disease and clinical remission an achievable goal for treatment. An increasing number of BA has become available in the last 15 years. However, some BA that have been associated to efficacy in some clinical conditions are not approved by legal authority for the use in pediatric population.
Highlights
Biologic agents (BA) have profoundly changed the outcome of juvenile idiopathic arthritis (JIA), making inactive disease and clinical remission an achievable goal for treatment
Etanercept, the first approved BA for pediatric use, was initiated in 378 patients (47.5%), of whom 377 (99.7%) after the approval date of the European medical agency (EMA) or Swissmedic (SM)
Adalimumab, infliximab and golimumab were used in 147 (18.5%), 106 (13.3%) and 14 (1.8%) patients, respectively; 75 (51.0%) patients were started on adalimumab before EMA/SM approval, whereas all patients on infliximab and golimumab were treated without EMA/SM approval
Summary
Biologic agents (BA) have profoundly changed the outcome of juvenile idiopathic arthritis (JIA), making inactive disease and clinical remission an achievable goal for treatment. Prescribed but not approved: biologic agents used without approval in juvenile idiopathic arthritis in Switzerland, France and Belgium Introduction Biologic agents (BA) have profoundly changed the outcome of juvenile idiopathic arthritis (JIA), making inactive disease and clinical remission an achievable goal for treatment.
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