Abstract
Damage Associated Molecular Pattern molecules (DAMPs) like HMGB1 have been demonstrated to be involved in pathological processes triggering and perpetuating autoimmune arthritis by attraction and activation of immune cells. The phagocyte-specific S100 proteins A8 and A9 (Myeloid Related Protein 8 and 14, respectively) are expressed by monoyctes and granulocytes and can likewise operate as DAMPs by signalling through TLR4 once released into the extracellular space.
Highlights
Damage Associated Molecular Pattern molecules (DAMPs) like HMGB1 have been demonstrated to be involved in pathological processes triggering and perpetuating autoimmune arthritis by attraction and activation of immune cells
Splenic T cell responses upon CII re-stimulation were studied in presence or absence of S100 protein priming of either whole splenocytes or bone marrow derived macrophages (BMDMs)
S100A9-/- mice were almost completely protected from collagen induced arthritis (CIA)
Summary
Damage Associated Molecular Pattern molecules (DAMPs) like HMGB1 have been demonstrated to be involved in pathological processes triggering and perpetuating autoimmune arthritis by attraction and activation of immune cells. The phagocyte-specific S100 proteins A8 and A9 (Myeloid Related Protein 8 and 14, respectively) are expressed by monoyctes and granulocytes and can likewise operate as DAMPs by signalling through TLR4 once released into the extracellular space
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