Abstract
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic anterior uveitis in childhood, and uveitis is the most frequent extra-articular manifestation seen overall in children with JIA. Although it is well-known that ocular involvement is strongly associated with a constellation of particular clinical features, which include the presence of antinuclear antibodies (ANA), young age at disease onset, female sex, and an asymmetric pattern of arthritis, the relative importance of each risk factor is still a matter of debate.
Highlights
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic anterior uveitis in childhood, and uveitis is the most frequent extra-articular manifestation seen overall in children with JIA
It is wellknown that ocular involvement is strongly associated with a constellation of particular clinical features, which include the presence of antinuclear antibodies (ANA), young age at disease onset, female sex, and an asymmetric pattern of arthritis, the relative importance of each risk factor is still a matter of debate
No association was found between the risk of developing uveitis and patient gender (p = 0.70) or ILAR category (p = 0.49), whereas the risk of developing uveitis was significantly associated with disease onset before 3.5 years (p < 0.0001) and with positive ANA (p < 0.0001)
Summary
Juvenile idiopathic arthritis (JIA) is the most common cause of chronic anterior uveitis in childhood, and uveitis is the most frequent extra-articular manifestation seen overall in children with JIA. It is wellknown that ocular involvement is strongly associated with a constellation of particular clinical features, which include the presence of antinuclear antibodies (ANA), young age at disease onset, female sex, and an asymmetric pattern of arthritis, the relative importance of each risk factor is still a matter of debate
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