Abstract
Ceragenins (CSAs) are a new class of antimicrobial agents that display broad spectrum antibacterial activity and may find use in the treatment of various infections. A member of this class CSA-13 was labelled with 99mTc using SnCl2·H2O as a reducing agent. The labelling efficiency depended on the ligand/reductant ratio, pH and volume of the reaction mixture. The radiochemical purity and stability of 99mTc-CSA was determined by thin layer chromatography. Biodistribution studies of 99mTc-CSA were performed in Sprague Dawley rats. Liver and spleen uptake was quite high. A significantly higher accumulation of 99mTc-CSA was seen at sites of S. aureus infected rats. The results were compared with 99mTc-Ciprofloxacin.
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