Abstract
The aim of this work was to develop a bioactive glass/chitosan (BG/CS) composite material for bone repair. Hydrochloric solution was properly mixed. Bioactive glass was added to make CS/BG mixed liquor. The microstructure and composition were observed and analyzed. The third-generation rabbit mesenchymal stem cells were inoculated into the stent. The adhesion of the stent was detected, and the proliferation of cells on the stent was detected. The compatibility between the stent and cells was evaluated. The size and shapes of the prepared CS/BG stents were consistent with moulds. Hydroxyapatite crystals gathered and no aggregation of BG was found. The rabbit mesenchymal stem cells adhered to the stent, and some cells extended and stretched out pseudopodia. Obvious proliferation of bone marrow stromal cells (BMSCs) was found on the stent. The CS/BG stent can be prepared by solution blending and freeze-drying technology. The prepared stents have good porosity, high mechanical strength and good cell compatibility. Key words: Bioactive glasses, chitosan, tissue engineering, bone fixation.
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