Abstract
A type of water-dispersive molecularly imprinted polymer/Au nanohybrids (nano-MIP/Au) was developed through macromolecular self-assembly for glucose recognition. A photo-crosslinkable random copolymer prepared from a series of acrylic esters and styrene was employed to co-assemble with glucose in aqueous solution. Au nanoparticles were synthesized in situ, employed AuCl4− as precursor, to generate nano-MIP/Au hybrids. The concentration of glucose and ionic strength can play an important role in the process of macromolecular self-assembly, which is discussed in this paper to testify non-covalent imprinting mechanism. To fabricate a MIP sensing interface, electrodeposition was utilized, followed by UV irradiation to make it robust with good stability. After extraction of glucose molecules, an MIP/Au sensor was constructed successfully. The existence of Au nanoparticles significantly enhanced the conductivity and sensitivity of the coating for glucose recognition. The superior performance is owing to water compatibility, large specific surface area of nanoparticles and direct electrical connection between the imprinting sites and electrode. The outstanding performance makes this kind of nano-MIP/Au attractive in biomolecule recognition, combined with its facile, green preparation procedure as well as low production cost.
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