Abstract
The ion-exchange behavior of 68Ga in mixed HCl–ethanol media on cation and anion exchangers was studied. The mass distribution coefficients of 68Ga on Dowex 50 W × 8 and Dowex 1 × 8 ion-exchange resins at HCl concentrations in the range 0.1–3.0 M and with ethanol volume fractions 0–90 % were determined. The dynamic characteristics of the 68Ga ion exchange in mixed HCl–ethanol solutions were studied. A process, based on the data obtained, was developed for preparing of 68Ga solutions in 0.1 M HCl with high chemical and radiochemical purity that are suitable for producing of 68Ga-radiopharmaceuticals with required quality for clinical use. The suitability of the process for the synthesis of different 68Ga-radiopharmaceuticals in routine clinical practice was demonstrated.
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