Preparation, characterization, antioxidant evaluation of new curcumin derivatives and effects of forming HSA-bound nanoparticles on the stability and activity.

Abstract

Curcumin (CCM) is a well-known active component, which has been studied extensively in food and medicine field since it showed various activities. However, some serious issues limit its application, for example, the extremely low solubility, stability and bioavailability. In this study, 10 Curcumin derivatives were synthesized and characterized by 1H NMR, 13C NMR and HR-MS, then their antioxidant activity was evaluated. Compound 2 and curcumin were further investigated by preparing HSA-bound nanoparticles (NP-2 and NP-CCM) to surmount the difficulties mentioned above. The nanoparticles obtained were about 110nm in size measured by Dynamic light scattering (DLS), the stability of compound 2 in NP-2 was significantly increased. Above all, NP-2 showed more efficient antioxidant and antitumor activity, which was probably attributed to the introduced isopentenyl groups in 2, it was supposed that the isopentenyl groups increased the interaction between compound 2 and HSA. Overall, NP-2 has great potential for some food and pharmaceutical applications.