Abstract
AbstractFour novel N‐substituted riluzole derivatives (4 a‐4 d) have been prepared and characterized. Their antinociceptive activities have been carefully investigated by hot‐plate test and writhing test. Our results indicated that at dose of 18 mg kg−1, 2‐(N‐propionic acid)‐6‐trifluoromethoxy‐benzothiazole (4 a), 2‐(N‐butanoic acid)‐6‐trifluoromethoxy‐benzothiazole (4 b) and 2‐(N‐n‐caproic acid)‐6‐trifluoromethoxy‐benzothiazole (4 c) significantly increased the nociceptive response latency under hot plate test while chemical nociception induced by intraperitoneal acetic acid was significantly inhibited by 4 a and 2‐(N‐proline)‐6‐trifluoromethoxy‐benzothiazole (4 d) at same dosage. Our research clearly indicates that N‐substituted Riluzole derivatives could be new alternative candidates as potential antinociceptive medicines.
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