Abstract
A novel stationary phase based on ionic liquid was prepared through thiol-ene click chemistry by functionalizing imidazolium and a carboxyl group for the mixed-mode liquid chromatography. The prepared material was characterized by elemental analysis, thermogravimetric analysis and FT-IR spectroscopy. The retention behavior of the stationary phase under different conditions (water content, pH, buffer concentration in the mobile phase and column temperature) was investigated. The interactions which occurred in the separation system were quantitatively studied by linear solvation energy equation and compared with two commercial columns. Moreover, the polar nucleosides and nucleobases, sulfonamides and inorganic anions were separated on a single mixed-mode column and exhibited high efficiency and flexible selectivity. In brief, the new stationary phase could be adapted to separate complex compounds with varying properties.
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