Abstract
Some inflammatory biomarkers are associated with the post-surgical prognosis in cancer patients. However, their clinical importance in gallbladder cancer has rarely been explored. The aim of this study is to assess the efficacy of surgical intervention and the effectiveness of preoperative test on neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) for predicting the prognosis in gallbladder cancer patients. In this study, a total of 255 gallbladder cancer patients were retrospectively selected. For each patient, we recorded his/her treatment algorithm (with or without surgery) and their preoperative inflammatory biomarkers, as well as their detailed survival information for 5 years. A total of 216 patients received surgical intervention and the other 39 chose conservative treatment. The median survival time was 4.6 months for non-surgical group (P < 0.001), and 12.2 months for surgical intervention group. Among the surgical group, ROC analysis showed the AUC of NLR, PLR and MLR were 0.675 (95% CI: 0.600 to 0.751, P < 0.001), 0.599 (95% CI: 0.520 to 0.677, P = 0.017) and 0.607 (95% CI: 0.529 to 0.686, P = 0.009), respectively. In conclusion, surgical intervention did improve the overall survival, and elevated NLR and MLR before surgery are associated with shorter OS of GBC patients.
Highlights
Preoperative platelet-tolymphocyte ratio and neutrophilto-lymphocyte ratio as predictors of clinical outcome in patients with gallbladder cancer
To the best of our knowledge, we find that data on the actual prognosis of surgical intervention in patients with gallbladder cancer is still scarce
Surgical intervention helps in improving the overall survival in our whole patient cohort, more obviously displayed in early stage Gallbladder cancer (GBC) patients
Summary
Preoperative platelet-tolymphocyte ratio and neutrophilto-lymphocyte ratio as predictors of clinical outcome in patients with gallbladder cancer. Their clinical importance in gallbladder cancer has rarely been explored. The aim of this study is to assess the efficacy of surgical intervention and the effectiveness of preoperative test on neutrophilto-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) for predicting the prognosis in gallbladder cancer patients. Surgical intervention did improve the overall survival, and elevated NLR and MLR before surgery are associated with shorter OS of GBC patients. GBC is marked by its insidious onset Often it is after the incipient symptoms have started to occur when the tumor tissue is discovered inadvertently. Patients are likely to present a rather poor recovery outcome, with a 5-year survival rate less than
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