Abstract
This study is focused on the development of clinically applicable nanocarriers for bone regeneration by establishing a systematic modeling guided nanocarriers development methodology. Firstly a drug release model is built through different release mechanisms to predict the profiles of drugs released from nanospheres. Then a cell response model is built through multiple signaling pathways related to the released drugs to predict the relationship between the drug profiles and the terminal cell phenotypes. Finally the cell response model combined with the drug release model will be employed to optimally predict the relationship between the input and output of the complete model, to establish an entire system with tunable input and output, and finally by optimal control to guide and accelerate the design of the BMP-2 and vancomycin incorporated nanocarriers.
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