Preliminary investigations of the binding ability of lima bean (Phaseolus lunatus) starch in paracetamol tablets

Abstract

The binding properties of starch obtained from Lima bean (Phaseolus lunatus) were evaluated. The starch from the seeds was extracted and the binding ability of its mucilage compared with that of maize starch mucilage in paracetamol based tablets at concentrations of 0, 2.5, 5, 7.5 and 10% w/v. The following properties of the starch powders were evaluated; organoleptic properties, microscopy and reaction with iodine solution while for the paracetamol granules prepared with their mucilages; particle size analysis, moisture content, flow rate, and angle of repose. The starches and granules were also evaluated for bulk and tapped density, Hausner’s ratio and Carr’s compressibility index. Paracetamol tablets formulated using the starch mucilages were evaluated for uniformity of weight, dimensions, hardness, friability, disintegration time and dissolution rate. The paracetamol granules and tablets formulated with 0 to 10% w/v P. lunatus starch mucilage were comparable in granule flow properties, tablet weight variation and hardness, friability, disintegration times and dissolution rate with the granules and tablets prepared with maize starch B.P mucilage. The study revealed that the mucilage of P. lunatus starch when used as binder produced tablets of acceptable pharmaceutical quality. Key words: Paracetamol tablets, wet granulation, Phaseolus lunatus starch, mucilage binder.