Preliminary findings of G8 and G8-modified as screening tools associated with quality of life in elderly patients with prostate, renal or bladder neoplasms in a Brazilian cancer center.

Abstract

122 Background: Population aging and cancer increased incidence are a public health challenge, as the elderly vary widely in terms of health status and aging process. Aiming at therapeutic efficacy and minimization of toxicities, treatment should be individualized. To aid in clinical decision and patient (pt) management, screening tools use is recommended, such as the G8 and the G8-modified (G8m), which identify geriatric problems: scored as abnormal when ≤ 14 and ≥6, respectively. These scales include health status self-assessment, which can be investigated by specific tools as EQ-5D-5L. The objective is to compare the G8 and G8m scales as screening tools in Brazilians ≥ 60 years old with urological tumors and describe Quality of Life using the Visual Analogue Scale of EQ-5D-5L (EQ VAS), which scores from 0-100 (higher better). Methods: Sociodemographic data were collected, and scales G8, G8m and EQ-5D-5L were applied to elderly people ≥ 60 years old with urologic cancer diagnosed within 6 months or prior to a change in therapeutic strategy, from Feb to Sep 2022. Statistical analyzes were performed, such as means, median, standard deviation and proportions, as well as comparisons of G8 total score versus G8m, using Kappa Coefficient. Fisher's Exact Test was used to analyze these scores related to sociodemographic data and the Pearson Correlation test to verify the relationship of the scores with the EQ VAS. Results: 43 pt aged ≥ 60 completed G8 with a mean score of 13,7(±2,2), G8m with 7,7 (±6,6) and EQ VAS 81,5 (±14,9). The mean age was 72,7 (±8,7) and 100% were men and 27 (62,8%) were white; furthermore, 9 (20,9%) lived alone. The most frequent cancer type was prostate 34(79,1%), followed by renal 5 (11,6%). 36 (83.7%) pt were changing treatment strategy and 7 (16.3%) had a diagnosis within 6 months. A weak agreement of 72.2% between normal G8 and G8m scores was identified (Kappa = 0.435 and p 0.006). A statistically significant association between normal G8m score and married marital status (p=0.039) was found, however there was no statistically significant association between G8 and G8m scores and comorbidities, smoking or polypharmacy. As well as no statistically significant correlation was found between the G8 and G8m scores with the Quality of Life measured by the EQ VAS. Conclusions: G8 and G8m demonstrated similar results in elderly pt with urologic tumors, identifying pt with frailties that are warranting a complete geriatric evaluation. In addition, this study indicates that it is better to assess quality of life using specific instruments, since the G8 and G8m scores were not correlated with the EQ VAS, although the screening scales included self-rated health. We intend to prospectively evaluate the prognostic power in the short term - 6 months, relating it to the quality of life, by the EQ-5D-5L.