Abstract
When encountering crime scenes where pregnant or recently post-partum women are involved it would be advantageous to identify a blood protein which indicates pregnancy or recent birth. A sandwich enzyme immunoassay for the detection of SP1, pregnancy specific B1 glycoprotein (detection range: 10–50 ng/mL) was evaluated and applied to 770 post-mortem dried stains from male, non-pregnant female and pregnant female blood. Circulatory SP1 was detected up to 8 days post-partum. The stability of SP1 in dried stains was monitored by exposing the stains to numerous environmental conditions where the presence of proteases were evaluated as a possible external parameter in the assay. Through validation, by demonstrating the specificity of the assay it was applied to homicide cases where SP1 in conjunction with genetic marker analysis proved a very effective identification method.
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