Abstract

AimTo clarify the effects of small endometriomas on in vitro fertilization (IVF) outcomes. In the present study, the potential impact of small ovarian endometriomas on the quantitative and qualitative outcomes of IVF was evaluated in the same individual.MethodsA retrospective analysis was performed, in which 118 infertile women with unilateral endometriomas that were <40 mm in size and who underwent IVF or intracytoplasmic sperm injection were evaluated. Single frozen embryo transfer cycles were performed, with separate data collections for both the affected and the unaffected ovaries, which allowed for an evaluation of the implantation rate.ResultsThe mean antral follicular count and the number of follicular flushings, retrieved oocytes, and obtained embryos were significantly lower for the endometrioma‐containing ovary than for the contralateral, intact ovary. No significant difference was observed regarding the blastocyst retrieval and good‐quality blastocyst retrieval rates, pregnancy rate, and clinical pregnancy or live birth rate.ConclusionAlthough the patients with a small endometrioma had a decreased ovarian reserve, they had lower pregnancy rates. The decision to transfer an embryo from an endometrioma‐containing ovary or from a contralateral, intact ovary also might not influence the pregnancy rate.

Highlights

  • Endometriosis is a disorder that is characterized by the presence and growth of endometrial tissue in ectopic sites.[1]

  • The quantitative ovarian reserve, embryo quality, and in vitro fertilization (IVF) outcome of women with a small endometrioma who undergo assisted reproductive technology (ART) but with a high average age remain a matter of debate because relevant evidence is scarce

  • The ovarian response was assessed by the total dose of gonadotropin that was required for ovarian stimulation, the number of follicles on the day that the oocyte was obtained, the number of retrieved oocytes, and the numbers of embryos that were obtained from the endometrial ovary and the contralateral, intact ovary

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Summary

| INTRODUCTION

Endometriosis is a disorder that is characterized by the presence and growth of endometrial tissue in ectopic sites.[1]. | 153 state that there is no evidence that cystectomy prior to treatment with ART improves the pregnancy rates in infertile women with endometriomas that are >30 mm. The Guideline Development Group recommends that clinicians only consider cystectomy prior to ART to improve endometriosis-­associated pain or the accessibility of the follicles.[8] In addition, it has been reported that surgery prior to scheduled ART does not benefit asymptomatic women with an endometrioma.[9]. The quantitative ovarian reserve, embryo quality, and IVF outcome of women with a small endometrioma who undergo ART but with a high average age remain a matter of debate because relevant evidence is scarce. The objective of the present study was to evaluate the quantitative and qualitative IVF outcomes in ovaries with and without a small (especially

| MATERIALS AND METHODS
| DISCUSSION
DISCLOSURES
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