Abstract

Major depressive disorder (MDD) is a leading cause of disability worldwide (1). This has only grown worse during the COVID-19 pandemic, with early estimates suggesting prevalence rates up to 25% (2). Although our understanding of depression has expanded greatly, current therapeutic treatments only work in a subpopulation of individuals (1). Clearly, more work is needed to develop effective treatments, and a necessary first step in that endeavor is to understand the neurocircuitry underlying MDD.

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