Abstract
The effects of gastric loads of 0.9% (W/V) NaCl, 5.25% glucose, 5% casein hydrolysate and Complan (a nutritionally complete diet) on food intake of rats, as measured by an operant response for food, were compared with the effects of gastric loads of the same materials after they had been predigested in donor animals. Predigestion was achieved by perfusion of the load materials through the stomach or duodenum of anesthetized donor rats. Gastric predigestion significantly reduced the inhibitory effect of the Complan load on food intake, and duodenal predigestion significantly increased the inhibitory effect of the saline load on food intake. Smaller nonsignificant changes in the effects of the other loads on food intake were also observed. The results are consistent with the hypothesis that gastric loads depress subsequent food intake at least partly because of the consequences of placing nonphysiological, i.e., undigested material in the stomach or duodenum of experimental animals.
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