Abstract
<b>Background:</b> Obesity is recognized as risk factor for obesity hypoventilation syndrome (OHS) which is associated with significant morbidity and mortality if not treated early. However, diagnostic predictors of chronic hypercapnia among obese patients remains unknown leading to delayed diagnostic and treatment. <b>Objective:</b> To determine diagnostic predictors of OHS among obese patients with suspected breathing sleep disorders (BSD). <b>Methods:</b> Retrospective analysis of data on 80 obese patients with suspected SBD (mean age 57,68 ±14,29 years; 77.7% females; mean BMI 40,66 ± 8). <b>Results:</b> Among 80 patients included, 34 had OHS while 46 were normocapnic. As compared with normocapnic obese patients, OHS patients had significantly higher Charlson comorbidity index (CCI) and mMRC score, significantly increased levels of glucose, CRP, urea, creatinine, hematocrit, uric acid, bicarbonate and significantly lower calcium and magnesium values. They also experienced significantly more severe sleep respiratory events (apnea hypopnea index (AHI), oximetry values) and significantly lower values of forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) and left ventricular systolic ejection fraction (LVSEF). Analysis of OHS predictors identified significant correlations between pCO2 and FEV1, FVC, SaO2, apnea hypopnea index (AHI), oxygen desaturation index (ODI) mean and minimum nocturnal SpO2, sleep time with SpO2 < 90%, pO2, and calculated HCO3 from the arterial blood gaz. <b>Conclusion:</b> Serum bicarbonate level and SpO2 may be a simple tool for early screening of chronic hypoventilation in obese patients.
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