Predictors for persistent urodynamic stress incontinence following extensive pelvic reconstructive surgery with and without midurethral sling.

Abstract

The objective of this study was to identify the predictors for persistent urodynamic stress incontinence (P-USI) in women following extensive pelvic reconstructive surgery (PRS) with and without midurethral sling (MUS). A total of 1,017 women who underwent pelvic organ prolapse (POP) surgery from January 2005 to December 2013 in our institutions were analyzed. We included 349 USI women who had extensive PRS for POP stage III or more of whom 209 underwent concomitant MUS. Of the women who underwent extensive PRS without MUS, 64.3% (90/140) developed P-USI compared to only 10.5% (22/209) of those who had concomitant MUS. Those with concomitant MUS and PRS alone were at higher risk of developing P-USI if they had overt USI [odds ratio (OR) 2.2, 95% confidence interval (CI) 1.3-4.0, p = 0.014 and OR 4.7, 95% CI 2.0-11.3, p < 0.001, respectively], maximum urethral closure pressure (MUCP) of < 60cm H2O (OR 5.0, 95% CI 3.0-8.1, p < 0.001 and OR 5.3, 95% CI 2.7-10.4, p < 0.001, respectively), and functional urethral length (FUL) of < 2cm (OR 5.4, 95% CI 2.7-8.8, p < 0.001 and OR 3.9, 95% CI 2.4-6.9, p < 0.001, respectively). Parity ≥ 6 (OR 3.9, 95% CI 1.7-5.2, p < 0.001) and Prolift T (OR 3.1, 95% CI 1.9-4, p < 0.001) posed a higher risk of P-USI in those with concomitant surgery. Perigee and Avaulta A seemed to be protective against P-USI in those without MUS. Overt USI with advanced POP together with low MUCP and FUL values have a higher risk of developing P-USI. Therefore, counseling these women is worthwhile while considering the type of mesh used.