Abstract
Objective To evaluate the predictive value of cord blood bilirubin levels for subsequent neonatal hyperbilirubinemia in term infants with ABO hemolytic disease. Methods A total of 292 term newborns with ABO hemolytic disease admitted from August 1, 2011 to July 31, 2012 were enrolled. Cord blood bilirubin levels were analyzed and the clinical characteristics of the neonatal hyperbilirubinemia group (n=34) and non-hyperbilirubinemia group (n=258) were compared. A receiver operating characteristic (ROC) curve analysis was performed to identify the predictive value of the occurrence and cut-off point of hyperbilirubinemia in term infants with ABO hemolytic disease. Paired-t-test, Chi-square test and Spearman correlation were used for statistical analysis. Results Of the 292 term infants with ABO hemolytic disease, 34 cases had hyperbilirubinemia, with an incidence of 11.6%. Cord blood bilirubin levels were significantly associated with the presence of hyperbilirubinemia. The mean cord blood bilirubin level in infants who developed hyperbilirubinemia was (52.4±13.2) μmol/L, and was (35.0±8.0) μmol/L for those who did not develop hyperbilirubinemia (t=7.540, P=0.001). When cord blood bilirubin concentration increased, the incidence of hyperbilirubinemia gradually increased (χ2=113.715, P<0.001; rs=7.19, P<0.001). The ROC area under the curve of 0.882 (standard error 0.005, 95%CI: 0.873-0.891, P<0.001) was significant in predicting neonatal hyperbilirubinemia by cord blood bilirubin, and the occurrence of hyperbilirubinemia increased with increasing cord blood bilirubin level. Neonatal cord blood total bilirubin ≥50 μmol/L predicted hyperbilirubinemia, and the positive predictive value was 0.683, negative predictive value was 0.959, sensitivity was 0.690 and specificity was 0.958. Conclusions Cord blood bilirubin level is useful in predicting subsequent neonatal hyperbilirubinemia in term infants with ABO hemolytic disease. Key words: ABO blood-group system; Blood group incompatibility; Hyperbilirubinemia, neonatal; Bilirubin; Fetal blood
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
