Abstract
Aim: To detect predictive value of preconception or early pregnancy sex hormone-binding globulin (SHBG) for subsequent gestational diabetes mellitus (GDM). Materials & methods: We searched Embase, Medline, PubMed, Web of Science and Cochrane library up to January 2020. Studies assessing diagnostic performance of SHBG for GDM diagnosed by well-defined diagnostic criteria using oral glucose tolerance test. Results: Totally seven studies with 1947 women were includedand 247 were diagnosed as GDM. SHBG had a combined diagnostic odds ratio of 6.68 (95%CI: 4.58-9.74), sensitivity of 0.70 (95%CI: 0.51-0.84), specificity of 0.74 (95%CI: 0.52-0.88), positive likelihood ratio of 2.49 (95%CI: 1.73-3.57) and negative likelihood ratio of 0.37 (95%CI: 0.23-0.61). The area under the summary receiver operating characteristic curve was 0.78 (95%CI: 0.74-0.82). Conclusion: SHBG had a predictive value for GDM and might improve GDM screening. However, heterogeneity between studies warrants more research into this topic.
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