Abstract
BackgroundSeveral previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. However, the factors are not yet determined.MethodWe retrospectively analyzed 123 previously healthy young adults diagnosed with COVID-19 from January to March 2020 in a tertiary hospital in Wuhan. Patients were classified as having mild or severe COVID-19 based on their respiratory rate, SpO2, and PaO2/FiO2 levels. Patients’ symptoms, computer tomography (CT) images, preadmission drugs received, and the serum biochemical examination on admission were compared between the mild and severe groups. Significant variables were enrolled into logistic regression model to predict the factors affecting disease severity. A receiver operating characteristic (ROC) curve was applied to validate the predictive value of predictors.ResultAge; temperature; anorexia; and white blood cell count, neutrophil percentage, platelet count, lymphocyte count, C-reactive protein, aspartate transaminase, creatine kinase, albumin, and fibrinogen values were significantly different between patients with mild and severe COVID-19 (P < 0.05). Logistic regression analysis confirmed that lymphopenia (P = 0.010) indicated severe prognosis in previously healthy young adults with COVID-19, with the area under the curve (AUC) was 0.791(95% Confidence Interval (CI) 0.704–0.877)(P < 0.001).ConclusionFor previously healthy young adults with COVID-19, lymphopenia on admission can predict severe prognosis.
Highlights
Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage
Logistic regression analysis confirmed that lymphopenia (P = 0.010) indicated severe prognosis in previously healthy young adults with COVID-19, with the area under the curve (AUC) was 0.791(95% Confidence Interval (CI) 0.704–0.877)(P < 0.001)
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which caused COVID-19, shows stronger infectivity than SARS-CoV and Middle East respiratory syndrome (MERS)-CoV, the mortality rate of COVID-19 is lower than SARS and MERS [3]
Summary
Several previously healthy young adults have developed Coronavirus Disease 2019 (COVID-19), and a few of them progressed to the severe stage. From December 2019 to March 2020, coronavirus disease 2019 (COVID-19) has been considered an epidemic in China, in Wuhan City, Hubei Province, where this disease initially emerged [1] According to data, this disease has already been considered a global epidemic because more than 200 countries have been affected, with more than 970,000 patients infected and 50, 000+ deaths [2]. Several previously healthy young adults who developed severe COVID-19, required superior oxygen therapy, including high-flow nasal cannula (HFNC), noninvasive positivepressure ventilation (NPPV), invasive positive-pressure ventilation (IPPV), and even extracorporeal membrane oxygenation (ECMO). We used our hospital’s data to determine the factors affecting patients’ clinical outcomes using an appropriate statistical model
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
