Abstract
AimTo identify predictive factors associated with non-deterioration of glucose metabolism following a 2-year behavioral intervention in Japanese-Brazilians.Methods295 adults (59.7% women) without diabetes completed 2-year intervention program. Characteristics of those who maintained/improved glucose tolerance status (non-progressors) were compared with those who worsened (progressors) after the intervention. In logistic regression analysis, the condition of non-progressor was used as dependent variable.ResultsBaseline characteristics of non-progressors (71.7%) and progressors were similar, except for the former being younger and having higher frequency of disturbed glucose tolerance and lower C-reactive protein (CRP). In logistic regression, non-deterioration of glucose metabolism was associated with disturbed glucose tolerance - impaired fasting glucose or impaired glucose tolerance - (p < 0.001) and CRP levels ≤ 0.04 mg/dL (p = 0.01), adjusted for age and anthropometric variables. Changes in anthropometry and physical activity and achievement of weight and dietary goals after intervention were similar in subsets that worsened or not the glucose tolerance status.ConclusionThe whole sample presented a homogeneous behavior during the intervention. Lower CRP levels and diagnosis of glucose intolerance at baseline were predictors of non-deterioration of the glucose metabolism after a relatively simple intervention, independent of body adiposity.
Highlights
Several anthropometric and metabolic parameters have been associated with cardiometabolic risk [1]
Prospective randomized controlled studies have shown that behavioral interventions targeting diet and physical activity can delay or prevent the progression from impaired glucose tolerance (IGT) to diabetes [6,7,8]
This study was able to identify baseline characteristics associated with the prevention of the progression of the natural history of glucose metabolism disturbances in two years
Summary
Several anthropometric and metabolic parameters have been associated with cardiometabolic risk [1]. Inflammatory markers have been studied as predictors of diabetes and cardiovascular events [2]. Japanese-Brazilians are considered as high cardiometabolic risk since they present high prevalence of disturbances of glucose metabolism and other cardiovascular risk factors [3,4]. Environmental factors should contribute to such picture and certain dietary habits were previously shown to predict metabolic syndrome in this population [5]. A behavioral intervention was Prospective randomized controlled studies have shown that behavioral interventions targeting diet and physical activity can delay or prevent the progression from impaired glucose tolerance (IGT) to diabetes [6,7,8]. The effect of lifestyle intervention varies among individuals and it would be helpful to identify those who benefit from an intervention and should be targeted considering such strategy
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