Abstract
A battery of methods for multivariate data analysis has been used to assess the associations between concentrations of fatty acids (FAs) and lipoprotein subclasses and particle size in serum for a normolipidemic population of ethnic Norwegians living in the rural Fjord region. Significant gender differences were found in the lipoprotein and FA patterns. Predictive FA patterns were revealed for lipoprotein features of importance for cardiovascular (CV) health. Thus, the subclasses of atherogenic small and very small low density lipoprotein (LDL) particles and the same subclasses of high density lipoprotein (HDL) particles were associated with a pattern of saturated FAs and mono-unsaturated C16-C18 FAs. Eicosapentaenoic acid (EPA) and the ratio of EPA to arachidonic acid (AA) had strongest associations to features that promotes CV health: (i) large average size of HDL and LDL particles, and, (ii) small average size of very low density lipoprotein (VLDL) particles. Total concentration of HDL in both genders correlated to EPA, but docosahexaenoic acid (DHA) correlated just as strongly for women. For men, docosapentaenoic acid (DPA) showed stronger association to HDL concentration than EPA. For both genders, concentration of large LDL particles showed associations to levels of EPA, but stronger to DHA and DPA. High values of EPA/AA seem to be the strongest single biomarker for good CV health in both men and women.Electronic supplementary materialThe online version of this article (doi:10.1007/s11306-015-0886-4) contains supplementary material, which is available to authorized users.
Highlights
The favorable impact of diets rich in omega-3 fatty acids (FAs) on the risk of developing cardiovascular diseases (CVDs), was suggested by the pioneering work of Danish researchers on lipids in plasma samples from Greenlandic Eskimos (Bang et al 1971; Dyerberg et al 1975)
The null hypothesis was identical medians and the Bonferroni correction for multiple testing was subsequently applied by assuming that the FAs and the lipoproteins could be considered as two families of tests since they belong to different classes of molecules and are measured independently by different instrumental procedures
After Bonferroni correction, average size and concentration of very low density lipoprotein (VLDL) is higher in men than in women (q \ 0.000001) and so is the concentrations of CM, VLDL-VL, VLDL-L, TG, all with q \ 0.000001, and, VLDL-M (q \ 00003) and apolipoprotein B with q \ 0.01
Summary
The favorable impact of diets rich in omega-3 fatty acids (FAs) on the risk of developing cardiovascular diseases (CVDs), was suggested by the pioneering work of Danish researchers on lipids in plasma samples from Greenlandic Eskimos (Bang et al 1971; Dyerberg et al 1975). They compared Eskimos living in Greenland with matching control groups of Eskimos living in Denmark and ethnic Danes and found that both triglycerides (TGs) and cholesterol (Chol) levels were lower for Eskimos living in Greenland than for the two control groups.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
