Abstract
Objective:To investigate any possible effects of mean platelet volume (MPV) on short-term stroke prognosis and functional outcome in patients with first-ever acute ischemic stroke (FEAIS).Methods:This retrospective cross-sectional study included 798 FEAIS patients admitted to the emergency department of a tertiary care hospital in Adiyaman, Turkey between January 2013 and June 2015. The data were evaluated according to whether alive or dead, MPV levels, modified Rankin scale (MRS) scores, National Institutes of Health Stroke Scale (NIHSS) scores. The patients were divided into 3 groups based on MPV level as 4.4-7.4 fL, 7.5-10.4 fL, higher than 10.4 fL.Results:A total of 250 patients with FEAIS were included in the study. In both those who survived and those who died, the area under the curve related to hospitalization days, time interval of venipuncture (TIV), and MPV measurements was not statistically significant (p>0.05). The 3 MPV groups showed no significant differences in terms of MRS score, median NIHSS score, hospitalization, and TIV. In subgroups based on MRS scores, there were no statistically significant differences according to median latency (p=0.087), median hospitalization (p=0.394), TIV (p=0.201), and MPV levels (p=0.847). Furthermore, there were no differences in MPV levels between the MRS based groups (p=0.527).Conclusion:The results showed that MPV was not a significantly associated and reliable marker for the prediction of prognosis or functional outcome of FEAIS attack.
Highlights
لدراسة أي آثار محتملة لمتوسط حجم الصفائح الدموية:الأهداف ) على تشخيص المدى القصير للسكتة الدماغية والنتيجةmean platelet volume (MPV)( الوظيفية في المرضى الذين يعانون من السكتة الدماغية الإقفارية
In both those who survived and those who died, the area under the curve related to hospitalization days, time interval of venipuncture (TIV), and MPV measurements was not statistically significant (p>0.05)
The 3 MPV groups showed no significant differences in terms of modified Rankin scale (MRS) score, median National Institutes of Health Stroke Scale (NIHSS) score, hospitalization, and TIV
Summary
The study data were retrospectively provided from an official hospital electronic patient database system that used the International Classification of Diseases-10 (ICD-10) coding system in accordance with stroke. The FEAIS patients primarily were assessed according to mortality (death or alive), MPV levels, and MRS score. During the time between venipuncture and processing, the samples were maintained at room temperature They were studied using optical laser light scatter analysis methods (Abbott, Cell-Dyn Ruby 3700, Chicago, Illinois, USA). Categorical data were analyzed using Pearson’s chi-square or the likelihood ratio test, where applicable, while the mean differences among groups were analyzed using one-way analysis of variance, and the Kruskal-Wallis test was used for comparisons of the medians. A p-value of
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