Abstract
Two-dimensional gas chromatography offers an unsurpassed and ordered separation combined with a very high peak capacity. Especially when applied to the separation and quantitative characterisation of complex mixtures it constitutes a leap forward with respect to state-of-the-art capillary GC. This is realised by the two orthogonal separations to which an entire sample is subjected. However, the selection of the proper combination of stationary phases and the temperature program is rather complicated and time consuming. A model is developed to predict which combination of columns is the most appropriate for a specified separation problem. The model is based on calculating retention times and peak widths of the compounds to be separated, on both columns, thus predicting the eventual chromatogram. It starts from estimating the retention factors ( k) of the compounds at their elution temperatures. This is performed with the help of the (calculated) vapour pressures and the enthalpic contribution to the activity coefficient as obtained from the Kováts retention indices. Some examples illustrate the usefulness of the model.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
